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Clomid |
Women
and Clomid
The drug seems
to have estrogenic effects on mood, which can be beneficial
(improving relationships with women by improving empathy)
or can yield depression or PMS-like symptoms, but for
most users there is no significant effect either way.
The claim
that duration of intake should not exceed 10-14 days
is incorrect. Clinical studies with male patients have
been for periods of a year or longer. This error probably
originates from the fact that, for use in women, due
to the menstrual cycle there would obviously be no
point in trying to stimulate ovulation all four weeks
of the month. Thus, use in women is limited to 10-14
days. That limitation is not because of toxicity.
Clomid is
in fact useful throughout a cycle if aromatizable drugs
are being used. We do think however that to be conservative,
one should use it no more than 2/3 of the time throughout
the year or a little less.
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Generic
name: Clomiphene citrate
Clomid is
the anti-estrogen of choice for improving recovery
of natural testosterone production after a cycle, improving
testosterone production of endurance athletes, and
is also effective in reducing risk of gynecomastia
during a cycle employing aromatizable steroids.
How
it works
While it has
been claimed that Clomid "stimulates" production
of LH and therefore of testosterone, in fact Clomid’s
activity is achieved not by stimulation of the hypothalamus
and pituitary, but by blocking their inhibition by
estrogen.
Clomid is a mixed estrogen agonist/antagonist (activator/blocker) which,
when bound to the estrogen receptor, puts it in a somewhat different
conformation (shape) than does estradiol. The estrogen receptor requires
binding of an estrogen or drug at its binding site and also the binding
of any of several cofactors at different sites. Without the binding of
the cofactor, the estrogen receptor is inactive.
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Different
tissues use different cofactors. Some of these cofactors
are able to bind to the estrogen receptor/Clomid complex,
but others are blocked due to the change in shape. The
result is that in some tissues Clomid acts as an antagonist
- the cofactor used in that tissue cannot bind and so
the receptor remains inactive - and in others Clomid
acts as an agonist (activator), because the cofactors
used in that tissue are able to bind.
Clomid is
an effective antagonist in the hypothalamus and in
breast tissue. It is an effective agonist in bone tissue,
and for improving blood cholesterol.
Clomid also
has the property of reducing the adverse effect of
exercise-induced damage of muscle tissue. This is very
significant for endurance athletes but is not very
significant, if at all significant, with reasonable
weight training. Clomid does not perceptibly affect
gains of the weight trainer either favorably or adversely
in my experience.
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